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Before the late 1980s, there were voluntary warnings, including a request to "avoid inhaling." Then came the first mandatory warnings: Smoking reduces life expectancy

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However, little is known about cannabis and tobacco co-use in adolescents at risk for psychosis. Substance use patterns tobacco only, cannabis only, co-use, other substances and no substance use were assessed over a two-year period in 734 individuals at clinical high risk for psychosis and 278 healthy controls

Ziricote bindings frame the body, fingerboard, and headstock, providing a dark, luxurious border that complements the instruments rich color palette