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As of September 10, 2025, recent research from the National Institutes of Health (NIH), JAMA Neurology, and the Cleveland Clinic has reinforced its efficacy, supported by clinical trials, meta-analyses, and real-world data involving thousands of participants

Figure 1 shows a schematic diagram of the process of surface-enhanced infrared spectroscopy based on silver nanoparticles for glutathione detection

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The expression of these genes is directly or indirectly regulated by Nrf-1 and Nrf-2 and coactivators such as peroxisome proliferator-activated receptor coactivator-1 (PGC-1) (227)