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CAFs are major regulators of tumor metabolic remodeling and affect cancer cell growth, drug resistance and immune escape through multiple metabolic pathways, such as glucose, amino acid and lipid metabolism [321]

every individual showed tolerance, and there were no serious side effects noted (Venkatasubramanian et al., 2016)

Presence of polyphenol, flavonoids and volatile compounds in the ethanol extract is involved in its antioxidant, anti-inflammatory and anti-apoptotic activities 43,44