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Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: efficacy depends on its baseline levels in the gut

Wild-type p53 may enhance susceptibility to cuproptosis by trans-activating genes involved in FeS cluster biogenesis (e.g., FDXR) and by rewiring cellular metabolism toward oxidative phosphorylation, thereby increasing reliance on mitochondrial respiration (49)