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In addition to phosphorylation, additional studies need to dissect the contribution of other PTM, such as acetylation and ubiquitination, and how they uniquely predispose alterations in the conformational state of tau to mediate propagation within afflicted brain circuits

What really matters is no new safety signals were identified with CagriSema beyond the known GLP-1 and amylin class effects

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Westermark, P., Wernstedt, C., OBrien, T

A dipeptidyl peptidase IV-stabilized potent GLP-1/PYY dual-acting analog demonstrated an improved capability of lowering the food intake compared to the stand-alone effect of GLP-1 and PYY [83]