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It exceeds the predicted energy demand [20]

Participants who supplemented with COQ10 also experienced less fatigue and increased muscle performance compared to placebo (Cooke 2008)

However, whether it is harmful or beneficial for subjects with mild cardiovascular diseases or even those without clinical manifestations is still controversial, likely because of the following reasons: (i) similar strains of mice in different studies from different suppliers differ in baseline bacterial gut microbiome, diet (e.g., different choline levels), age of the mice, animal housing conditions, and duration of the experiment

Also, KD is not entirely free of side effects, with fatigue, muscle cramps, hypotension, constipation, and unwanted weight loss being the most commonly reported (125)