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Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis

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when GC is activated, its catalytic intracellular domain can catalyze the decomposition of guanosine triphosphate, which leads to an increase in cyclic guanosine monophosphate (cGMP) levels in the cytoplasm and causes vascular smooth muscle relaxation through the cGMP-protein kinase A pathway (77)

Anti-hypertensive angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patients

By virtue of this influence, GSH production encounters inhibition, ushering in a cascade of cellular responses (Yang et al., 2014)