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Studies have shown that individuals with low B12 levels may experience fatigue, brain fog, and mood changessymptoms that often improve with consistent supplementation

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The 2026 Sports Medicine and JAAOS Global Research and Reviews papers (PMID 41966639, PMID 41490200) place multiple compounds including this one into the wider research context of unapproved compounds under active investigation, with attention to both the mechanism findings and the regulatory framing that researchers consulting these reviews should weigh equally

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This means that even if you do have a vitamin B12 deficiency, your body will likely be able to compensate for this at least from a methylation perspective via your dietary choices