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The antioxidant protection of pancreas is associated with the removal of hydrogen peroxide by GPx-1

Dexrazoxane, an iron-chelating agent, is FDA-approved for cardioprotection in patients receiving high cumulative doses of doxorubicin and has shown efficacy in reducing cardiac events without significantly compromising antitumor activity

The human equivalent dose for the cyano- and methyl-cobalamin drinking water used in these studies is ~5000 g/day (CNCbl10 & MeCbl10) and ~25,000 g/day (CNCbl40 & MeCbl40), which was calculated using the standard human equivalent dose parameters [18]