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Localisation of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs

10.1021/acschemneuro.5b00093 ACS Chem

The differentiation process of Th1 cells is tightly regulated by a feedback loop, with Th1 differentiation mainly regulated by TF T-bet, which can promote IFN- secretion by upregulating IL-12R 2 receptor expression and T-bet expression regulated by signal transducer and activator of transcription 1 (STAT1), which is in turn activated by IFN- secreted by TH1 cells (133)