DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan building block 562 SMILES OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCOCCOCCOCCN=[N+]=[N-])C1=CC=C(O)C=C1O2 Purity (HPLC)

562 SMILES OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCOCCOCCOCCN=[N+]=[N-])C1=CC=C(O)C=C1O2 Purity (HPLC) 98% Shipping Conditions Room Temperature Storage Conditions Refrigerated Regulatory Statemen: For Research Use Only

Product Name tert-butyl 2-(piperazin-1-yl)acetate Synonyms CAS Number 112257-22-4 Related CAS Molecular Formula C10H20N2O2 Molecular Weight 200

Product Name Thalidomide-propargyl-C1-amine HCl Synonyms Thalidomide-4'-propargyl-C1-amine HCl CAS Number n/a Related CAS Molecular Formula C17H16ClN3O4 Molecular Weight 361

265 SMILES NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Trametinib Synonyms CAS Number 871700-17-3 Related CAS Molecular Formula C26H23FIN5O4 Molecular Weight 615

DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan building block 562 SMILES OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCOCCOCCOCCN=[N+]=[N-])C1=CC=C(O)C=C1O2 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC