Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4) Alexa Fluor 488 DCAF1-based PROTACs with activity against

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

42 SMILES CC(C)(C)OC(=O)NCCN1CCN(CCCN)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

HaloTag PEG4 Azide Ligand CAS Number Related CAS Molecular Formula C14H28ClN3O4 Molecular Weight 337

and biochemical research

a Mal-Propionyl-Dap(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility

Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4) Alexa Fluor 488 DCAF1-based PROTACs with activity againstSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase