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The cited pharmacological study has demonstrated that curdione modulates redox complexes by disrupting Keap1-Trx1 interactions while enhancing Trx1-GPX4 binding, thereby attenuating post-infarction ferroptosis through Keap1/Trx1/GPX4 axis regulation (64)

Tsalic M, Bar-Sela G, Beny A, Visel B, Haim N (2003) Severe toxicity related to the 5-fluorouracil/leucovorin combination (the Mayo Clinic regimen): a prospective study in colorectal cancer patients