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Additionally, the GM also produces some neuroactive metabolites such as neurotransmitters or their precursors

This alteration can cause damage to the colonic mucus barrier and result in the development of colitis caused by the enteric pathogen Citrobacter rodentium [136]

Seizures may be treated efficiently by life-long supplementation with pyridoxine or its biologically active form, pyridoxal phosphate, but even so patients may become intellectually disabled, for which there currently is no effective treatment

The S protein is metastable when produced as a recombinant protein and prone to transform from its pre-fusion to a post-fusion conformation, shedding the S1 subunit (Fig

A plaques result from the abnormal cleavage of amyloid precursor protein (APP) by betasecretase (BACE1) and gammasecretase, leading to the aggregation of A peptides, particularly A42, which is highly toxic to neurons (Hardy and Selkoe 2002)