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A marked reduction in respiratory complex I, II/III, and IV activities were observed in both liver and kidney of GK rats (Figures 5AC)

Ethical principles of the study complied with the European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), Federation of European Laboratory Animal Science Associations (FELASA) recommendations, and the recommendations of the Ethics Committee of the School of Medicine, University of Zagreb

It is also interesting to note that patients who have had gastric bypass surgery (usually a treatment for obesity) may have altered alcohol metabolism, with faster absorption and slower metabolism

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Use of either glucocorticoids or megestrol acetate administered at the lowest effective dose can be considered to improve appetite while minimizing potential side effects