NRX-252114 amine-amine NRX-2663 acts as molecular glue

NRX-2663 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome

Product Name: Tetramethylrhodamine-5 C2 maleimide Synonyms: Tetramethylrhodamine-5 C2 maleimide CAS Number: N/A Molecular Formula: C31H28N4O6 Molecular Weight: 552

Product Name 4-bromo-3-(methoxy-d3)-benzaldehyde Synonyms CAS Number n/a Related CAS Molecular Formula C8H7BrO2 Molecular Weight 218

Product Name DOTA-tris(t-Bu)ester-C5-amine Synonyms CAS Number n/a Related CAS Molecular Formula C33H64N6O7 Molecular Weight 656

44 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(OCCOCCOCCOCC#C)=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

NRX-252114 amine-amine NRX-2663 acts as molecular glueNRX 252114 is an enhancer of the interaction between beta catenin and beta TrCP. NRX 252114 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta catenin by the 26S proteasome. Product Name NRX 252114 Synonyms CAS Number 2763260 39 3 Related CAS Molecular Formula C22H12Cl2F3N3O2S Molecular Weight 510. 31 SMILES FC(F)(F)C1=CC(SC2=C(Cl)C=CC=C2Cl)=C(C(=O)N2CC3=CC=CC(C#N)=C3C2)C(=O)N1 Purity (HPLC) >= 95%