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From a pathological evolution perspective, IVDD begins with the progressive destruction of the nucleus pulposus: the early stage is characterized by increased degradation of proteoglycans, leading to decreased water content in the NP and weakened biomechanical performance (reduced compressive load capacity), transferring more stress to the annulus fibrosus

10.3390/plants12244074 236

Extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them

Hampstead BM, Sathian K, Bikson M, Stringer AY (2017) Combined mnemonic strategy training and high-definition transcranial direct current stimulation for memory deficits in mild cognitive impairment

Adipocytes modulate the electrophysiology of atrial myocytes: implications in obesity-induced atrial fibrillation