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doi:10.1111/jhn.12493 ^ Ahlgren G., Lundstedt L., Brett M., Forsberg C

No validated human pharmacokinetics A human half-life, bioavailability, tissue distribution, metabolic pathway and exposure-response relationship have not been established through a published clinical programme

Viewed from this perspective, mTORC1 is a pro-oncogenic factor as it represses autophagy by either directly inhibiting multiple stages of autophagy or indirectly regulating lysosomal biogenesis (Rabanal-Ruiz et al., 2017) (Figure 2)

Few works have applied these models to study ECD but not always in the context of CVDs

Single-cell transcriptomics reveals the aggressive landscape of high-grade serous carcinoma and therapeutic targets in tumor microenvironment