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Description

These three biological states appear to be able to influence one another in a self-sustaining cycle (Nguyen et al., 2011) forming a neurotoxic triad. Figure 1 illustrates the self-sustaining interaction between excitotoxicity, oxidative stress, and inflammation (which are reviewed below), while also presenting some nutritional deficiencies which can fuel the triad

ZouYWangFWangYSunQRHuYLiYZet al

Understanding these deep cellular mechanisms is crucial when exploring how a doctor diagnoses Long COVID and why one-size-fits-all treatments often fail