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[50] Both areca nut and betel leaf chewing, however, can cause premalignant lesions such as leukoplakia and submucous fibrosis, and are recognized risk factors for oral and oropharyngeal squamous cell carcinoma (oral cancer)

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Furthermore, salt-adapted cells showed abundant vesicles close to the plasma membrane labeled JIM13 and a well-developed endomembrane system with an important labeling of JIM13 in the trans-golgi region (Figures 2E,F)

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