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J Pharmacol Sci 137:387394 Etoh T, Inoguchi T, Kakimoto M, Sonoda N, Kobayashi K, Kuroda J, Sumimoto H, Nawata H (2003) Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment

Some investigators have examined both peptides concurrently in tissue repair models, noting that their non-overlapping pathways may produce complementary downstream effects on vascularization and extracellular matrix remodeling

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Cell 73 , 354363.e353 (2019)

We have reported that down-regulation of renal GRK4 expression, via ultrasound-targeted microbubble destruction-delivered Grk4 small interfering RNA (siRNA), decreases blood pressure, accompanied with increased sodium excretion in SHRs [21, 81]