Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4) oregon green Visualizing inflammation with an M1

Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target

a highly potent topoisomerase I inhibitor derived from camptothecin

This is a big advantage in living systems

Sulforhodamine 101 alkyne (Texes Red alkyne) is an excellent azide-reactive fluorescent reagent for labeling azide-containing biological molecules through click chemistry

This modification allows for distinct labeling applications

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4) oregon green Visualizing inflammation with an M1SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX