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Kumagai, H., Yoshikawa, T., Zempo-Miyaki, A., Myoenzono, K., Tsujimoto, T., Tanaka, K., & Maeda, S

In addition, the pleiotropic metabolic effects of SGLT2 inhibitors make it difficult to attribute the observed changes solely to immune or signaling modulation rather than secondary metabolic improvement

In clinical studies, higher levels of circulating long- and medium-chain acylcarnitines showed mixed results in patients with Alzheimers disease [24, 25] whereas clinical trials of patients with Parkinsons disease have consistently shown that circulating levels of long-chain acylcarnitines are decreased [26,27,28]