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Over time, the regulatory system will need to move on from harm reduction (which forms the basis of the APPH test) to define a regulatory framework for the use of nicotine as a lawful, mildly psychoactive yet potentially addictive substance

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Thus, non-competitive agonists that blockade the NMDA receptor, such as ketamine or phencyclidine (PCP), have been increasingly used in animal models of schizophrenia and have been shown to induce hyperlocomotion, social withdrawal, and impairment of both cognition and pre-pulse inhibition in rodents [100]

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