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If given to elderly patients, diphenhydramine can cause confusion and agitation

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However, a more recent study has described impaired endothelial function even after a single nicotine-free ENDS session that was also accompanied by increased inflammatory mediators (i.e., serum CRP, plasma HMGB1) and oxidative stress [117]

Figure 7 Predictions of burden Based on the BAPC analysis, we projected that the deaths and DALYs of all substance use subtypes will decrease consistently from 2022 to 2040, with the exception of drug use and chewing tobacco