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For the second issue, the name was tweaked to The Lives They Lived, perhaps to accommodate fascinating scoundrels, and it was declared the start of a tradition

Due to the extensive diversity of TCRs and the complexity of antigen-epitope-TCR interactions (where a single antigen can contain multiple epitopes, each potentially recognized by a variety of TCRs), our current results cannot directly clarify the nature of antigen specificity in CD4 and CD8 T cells within COPD airways

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To evaluate the robustness of the IVW estimate and explore potential horizontal pleiotropy, we performed a series of sensitivity analyses