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A massive problem for smokers is not only the nicotine addiction itself, but the quantity of nicotine that smoking takes into the body

these cells subsequently enter the arterial wall and promote atherosclerosis.95 In young adults who chronically used electronic cigarettes, FDG-PET CT showed increased uptake in the spleen and aortic wall compared with non-users, which is consistent with the engagement of the splenocardiac axis by the substances released by these devices.96 The effect on physical properties of the cardiovascular system come from a study of mice exposed to electronic cigarette vapours for 8 months (4 hours a day for 5 days a week, emulating an equivalent of 20 years of exposure in humans)

Eat Behav 2006 Nov

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Tissue damage: Hot, chemical-laden smoke irritates soft tissues and increases the risk of infection