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Cultural Significance: They have a cult following and are often associated with outdoor, rugged smoking experiences

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If the car will not be used for several days: Inspect the engine bay before leaving Clean the cabin and boot Remove all food Park in a clean, well-lit area Ask someone to inspect the vehicle periodically Check beneath the bonnet before starting it again Starting the engine alone is not always sufficient

Furthermore, nicotine has been shown to induce endothelial damage and apoptosis [23], with other studies suggesting that nicotine consumption through ENDS promotes tissue remodeling, causing vascular dysfunction via damaged endothelium [24]