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The downregulation of PRKN in lung epithelial cells of COPD patients may contribute to the deficiency in mitophagy observed in these patients, leading to the accumulation of aberrant mitochondria and increased oxidative stress within cells ( In vitro experiments have suggested that even low levels of PINK1 expression can be compensated by increased PRKN expression, leading to induced mitophagy and reduction of cellular ROS stress during CS exposure, a major risk factor for COPD ( 3.2 Mitochondrial dynamics in COPD Mitochondrial morphology and dynamics are altered in the lung cells of COPD patients

Thus, prior to each quarterly payment, we propose to provide the ACO with the notice described above in the form of a report that shows our calculation of the ACO's quarterly prepaid shared savings amount

10.1093/nar/gkaa804 31 FriedmanJ

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