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In Cratylus, Plato has Socrates report that a swarm of wisdom has come into my mind. When asked what sort of swarm, Socrates answers vaguely, I seem to picture Heraclitus uttering ancient words of wisdom that everything is in motion and nothing remains as it is, and he compares things that are to the flow of a river, saying that you cannot step twice into the same river. James knew his Plato, of course, but the more immediate source for his reworking the metaphor of streaming water for thinking was Ralph Waldo Emerson, who according to a family story blessed baby William during one of his visits to the James household

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Notably, despite correlating with more severe hemodynamic abnormalities (e.g., elevated mPAP and PVR), higher circulating miR-424/322 confers a better prognostic outcomeparticularly in patients with congenital heart disease-associated PAH (CHD-PAH)

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(2014) were assessed [32]