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the major psychoactive substance in tobacco is Classification of Substances 2-Minute Neuroscience: Nicotine

Name: the major psychoactive substance in tobacco is Classification of Substances 2-Minute Neuroscience: Nicotine
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2 Minute Neuroscience: Nicotine Tobacco Users Smoke Crack Health effects of smoking tobacco Wikipedia Chemicals in cigarettes #cigaretteschemicals #biologyfacts Psychoactive Drugs Tobacco, Alcohol, and Illicit Substances PDF

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In the end it was concern over infectious diseases which turned public opinion against the option to simply spit on floors and sidewalks

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Interestingly, despite nicotines high dependence rate, it takes the longest to develop (27 years), while cocaine and cannabis lead to dependence much faster (4-5 years)