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Consistent with this inhibitory effect of DNA methylation on DNA transcription, CpGs within 1 kb of transcription start sites are generally hypomethylated (Bell et al., 2011

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Many studies of tobacco use and asthma did not assess cigarette smoking history, use of multiple tobacco products and other smoke exposures, such as secondhand smoke and marijuana use, that could be confounders,16 18 2225 and most prospective studies of asthma and tobacco did not account for COPD.16 17 2226 (Up to one-third of adults with asthma eventually develop comorbid COPD,27 28 when patients present with features distinct from asthma.29 30) For example, a recent paper22 noted that combustible tobacco and e-cigarette use were both associated with adult-onset asthma

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