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Cigarette Smoking and Schizophrenia: Etiology, Clinical, Pharmacological, and Treatment Implications PMC Factors promoting tobacco use in schizophrenic patients: IV. Download Scientific Diagram Study: Smoking May Increase Risk of Schizophrenia Can Smoking Compromise Antipsychotic Efficacy in Schizophrenia? The interaction between smoking and schizophrenia is complex and multifaceted, with patients consistently showing higher rates of tobacco smoking and heavy nicotine dependence. One important The Intrinsic Receptor Deficit In the general population, chronic smoking leads to an upregulation of 42 nicotinic receptors. In schizophrenia, this compensatory upregulation is impaired. This suggests an intrinsic defect in the

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