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Day had the opportunity to play more dramatic parts she most notably played James Stewarts wife in the Alfred Hitchcock thriller The Man Who Knew Too Much , where she debuted her signature song, Que Sera Sera. But she always turned away from more nuanced roles in favor of sticking to type in frothier rom-coms or as they were often dubbed at the time, sex comedies. All of Days romantic comedies had a distinct formula designed to reward the female virgin for holding out: Time and again, her cheeky, assertive, yet firmly conservative ways would captivate a bevy of roguish leading men Rock Hudson, Clark Gable, Cary Grant and ultimately charm them into giving up their playboy lifestyles and proposing marriage

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Abstract Cigarette smoke (CS) imposes continuous oxidative and electrophilic stress that disrupts cellular homeostasis in the lung