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In extreme cases, a blockage forms that causes gangrene and will require amputation

People who smoke cigarettes are 15 to 30 times more likely to be diagnosed with lung cancer than nonsmokers, according to the US Centers for Disease Control and Prevention, which also linked cigarettes to cancer almost anywhere in the body. Research cited by the FDA indicated a ban on menthol cigarettes could lead to a 15% decrease in smoking overall over the next 40 years, preventing between 324,000 and 654,000 smoking-related deaths

We use per se pretty literally, meaning in itself, intrinsically

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