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Granted, you're not holding smoke in your lungs as long as Notap's experiment does, but the final result is pretty grim

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Specifically, ethanol has been suggested as an activator of cholinergic afferents, causing the release of acetylcholine in the ventral tegmental area, leading to nAChR stimulation, followed by excitation of the mesocorticolimbic dopamine system 14

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Prokhorov AV: Interventions for high-school and college students guided by the Transtheoretical Model of Change