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Tobacco smokers display an increased gingival microvascular density with considerable gingival inflammation, suppressed angiogenesis due to local immune suppression, and oxidative stress leading to periodontal disease and increased risk of complications 44

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Continual puffing during the 20 minutes achieves maximal effect

Furthermore, the studys findings are limited by the absence of detailed information on other potential confounding factors, such as dietary habits, genetic predispositions, and socioeconomic status that could influence the development of ALD and HCC