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The liver naturally contains some fat, but when more than 5% of hepatocytes (liver cells) are affected by fat accumulation, it becomes pathological

Daneshpour S, Bahadoran M, Hejazi SH, Eskandarian AA, Mahmoudzadeh M, Darani HY

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In its evaluation, the FDA found the products contain lower levels of most harmful and potentially harmful constituents compared with other oral and smokeless tobacco products, with many constituents too low to be quantified