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Br J Clin Pharmacol 47:445449 Seppala NH, Leinonen EV, Lehtonen ML, Kivisto KT (1999) Clozapine serum concentrations are lower in smoking than in non-smoking schizophrenic patients

A negative linear relationship between PdG and number of cigarettes smoked was also observed and is largely consistent with prior research suggesting that progesterone reduces the propensity to smoke, likely through its positive effects on ALLO and, in turn, GABAergic transmission (GABA) [25]

These consequences are heightened in developing bodies and brains, making teens and young adults who are most likely to vape even more susceptible than their older counterparts

The law, which took effect on April 24, 2026, brought nicotine-containing vaping products, including synthetic nicotine products, under tobacco regulation

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