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In 2016 a meta-analysis of previous studies was published

According to Chamorro-Garcia, the findings indicate that metabolic changes observed in the offspring were not caused by other byproducts found in cigarettes or additives used in e-cigarettes

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Cigarettes have been a part of human culture for centuries, evolving from hand-rolled tobacco leaves to the mass-produced products we see today

Cigarette smoke contains over 4000 chemical compounds including ROS, reactive nitrogen species (RNS), nitric oxide (NO), and free radicals of organic compounds 11