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In addition there are several other things that can bring on a bout of acid reflux including: Muscle relaxants like ibuprofen, also relax the LES muscles and keep the valve open Aspirin causes irritation of the stomach Certain health conditions like diabetes, pregnancy, and stress can aggravate acid reflux by loosening the LES Constant stress can cause you to overproduce digestive acid What Can You Do Some Natural Treatments As I tell my patients, we can all experience a bout of heartburn, or perhaps even acid reflux, on occasion from overindulgence in food and drink