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Given the critical role of extracellular matrix composition in regulating epithelial differentiation [44], we evaluated four distinct hydrogel substrates: 100% collagen (COL), 70% collagen/30% Matrigel (C7M3), 30% collagen/70% Matrigel (C3M7), and 100% Matrigel (MG)

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This is seen notably when total consumption estimated through survey data (hereafter called reported consumption, following Kenneth Warners terminology [14]) is compared with consumption figures estimated from national aggregate data (hereafter called actual consumption, again Warners terminology [14]): shortfalls of up to 33% have been observed, which means that reported consumption accounted only for two thirds of actual consumption [14, 15]