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Current evidence supports the dopaminergic hypothesis as one of the pathophysiological hypotheses for negative symptoms in SCZ, which proposes that positive symptoms are the result of overactive dopaminergic neurotransmission in the limbic pathway, whereas negative symptoms are thought to be caused by low dopaminergic function in the frontal lobes and other limbic structures of the midbrain 7,43

COVID-19 is most likely transmitted through close contact with a person while they are infectious or 24 hours before their symptoms appeared, or close contact with a person with a confirmed infection who coughs or sneezes

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29 However, the feeling of relaxation is temporary and soon gives way to withdrawal symptoms and increased cravings