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3.4 Association between e-cigarette users and the prevalence of COPD The meta-analysis suggested a statistically significant association between current e-cigarette use and the increased prevalence of COPD, with a pooled OR of 2.03 (95% CI: 1.612.56), indicating a 103% higher prevalence compared to never-smokers, which is defined as lifelong smoking of less than 100 cigarettes or never participating in smoking or using any tobacco products, including e-cigarettes