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Perhaps the greatest utility of toxicity testing of cigarette smoke and condensate comes from the ability to explore mechanisms by which tobacco and the constituents of its smoke cause disease, to identify better biomarkers of potential disease risk for use in both clinical and population-based studies, and possibly to evaluate the relative contribution of cigarette components and design features (e.g., additives, tobacco blends, nontobacco components, and filter ventilations) to the inherent toxicity and addictiveness of the product

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