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If a higher volume of submissions is received than is currently expected, FDA intends to ensure that entities who submit an adequate plan by the recommended submission date and who work in good faith with FDA to complete its review are not delayed or prevented from distributing or advertising cigarette packages or advertisements due to the agency not having approved their plans by the effective date of the final rule

Many smokers shun trying electronic cigarettes because they are convinced they dont taste like real cigarettes

Genotoxicity As a direct consequence of a reduction in carcinogenic toxicant emission, cMRTP aerosols should display significantly reduced mutagenicity and genotoxicity in standard cell-based assays, such as the Ames, in vitro micronucleus and the mouse lymphoma assays [32, 50]

The majority were small bowls, tobacco boxes, and tea glass holders