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"Conversely, if dopamine function normalizes with abstinence this rather indicates that alterations were induced by substance consumption." One limitation of the study is its small size, which makes it difficult to draw statistically meaningful conclusions, the authors note

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Philippe did not give a timeline for the price hike, which he said would be accompanied by a merciless fight against traffickers who undermine this policy. French smokers already pay some of the highest prices for cigarettes in the European Union, surpassed only by Britain and Ireland.

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Other studies report population-level life-years lost due to smoking or gained from tobacco control interventions in the U.S