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Nicotine Replacement Therapy (NRT) , including gum, lozenges, patches, mouth spray and inhalers, offers a medically approved and controlled way to deliver nicotine without the toxicants found in tobacco

NtZIP1-like is involved in supplying internal tissues of younger organs with Zn (primarily under deficiency), while NtZIP11 specifically participates in the uptake of Zn excess in plants exposed to its high, toxic concentrations, contributing to the accumulation of a high amount of this metal in older tobacco leaves (Papierniak et al

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it's the other toxins in cigarette smoke, like carbon monoxide and tar, that harm blood vessels