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[1] [2] Major Outcomes of the Master Settlement Agreement (MSA) MSA led to three major results as described below: States gaining a monetary compensation for smoking related health care costs induced by the tobacco companies (Image 1) Enforcement of restrictions on advertising, marketing and promotion of tobacco products Public gaining access to internal documents of tobacco companies (Image 2) Monetary Compensation for Smoking Related Health Costs As a condition of the MSA tobacco companies agreed to pay approximately USD 206 billion (based on a calculation made by an independent auditor) as an annual payment to the states to compensate the health care costs borne by the public tax

1 Callaghan et al: Patterns of tobacco-related mortality among individuals diagnosed with schizophrenia, bipolar disorder, or depression

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(2019) demonstrated that nicotine treatment decreased estradiol production as well as mRNA expression of 17-HSD1 and P450arom, and even at the protein level there was significant reduction of P450arom expression implying the inhibition of estradiol synthesis by ovarian granulosa cells

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