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As the tobacco industry blossomed into an imposing entity, shaping economies, societies, and personal lives, it flickered against the backdrops of eras, marking time with its evolving image, practices, and influence

Also, although biomarkers typically represent only recent exposures, the strongest determinant of risk for many diseases (e.g., lung cancer) caused by tobacco use is the duration of smoking (IARC 2004)

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Additional analysis results on RRs from updated datasets with a longer follow-up period and analyses adjusting for confounding variables such as age and alcohol drinking were obtained through personal communication with the authors of cited publications [21, 27, 31, 35]

Philadelphia, PA: Elsevier Saunders